A Semi-Automatic Real-Time Three-Dimensional Digital Doppler Method for Measurement of Flow Volumes in Children:A Validation Using Cardiac Magnetic Resonant Imaging
Honghai Zhang, Liping Bu, Alan Stolpen, Milan Sonka, Shuping Ge
Poster presented at American Heart Association, Scientific Session 2004
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Abstract
The goal of this study is to validate the feasibility and accuracy of a semi-automatic real-time 3-dimensional digital Doppler (RT3DDD) method as a non-invasive clinical and research tool for measurement of flow volumes.
Methods: A total of 13 children (10.5 ± 2.5 years, 8 male and 5 female, 12 healthy subjects and 1 with unexpected atrial septal defect) were enrolled. A Sonos 7500 ultrasound system with X4 matrix transducer was used to acquire the 3D Doppler velocity data across the mitral valve orifice from an apical window (12-19 frames per cardiac cycle, 80x80x208 array for each frame). MRI was performed using a GE CV/i 1.5T scanner with a torso coil. 2D phase velocity cine MRI (PVC MRI) were acquired in a plane perpendicular to the long axis of the ascending aorta (AO) to derive the stroke volume (AOSV). Short axis 2D Fiesta images of the left ventricle (LV) were also acquired to measure SV (LVSV). The 3D Doppler velocity data was analyzed off-line using custom software developed at the University of Iowa (UI) based on the Gaussian control surface theorem. The flow across the mitral valve were automatically identified and unwrapped using our algorithms and the flow rates and volumes calculated.
Results: In 234 out of all 260 frames of RT 3DD data from 13 study subjects, the flow regions were successfully segmented using our automatic method. In the remaining 26 frames, which happened between the E-peak an A-peak of diastole, manual tracing produced better segmentation results than automatic method. The SV measured at the mitral valve orifice by this semi-automatic RT 3DDD method correlated well and agreed well with both the AOSV measured at the ascending aorta by PVC MRI (Pearson test: r = 0.92, y = 0.92 x + 0.91 ml, SEE = 12.27 ml, p < 0.05. Bland-Altman: mean difference -5.23 ml ± 11.55 ml, P > 0.05) and SV by LV volumetric measurement by MRI (Pearson test: r = 0.94, y = 0.94 x + 3.93 ml, SEE = 10.62 ml, p < 0.05. Bland-Altman: Mean difference = -0.15 ml ± 9.92 ml, P > 0.05). Conclusions: This study demonstrates that measurement of cardiac flow volumes through the mitral valve by this semi-automatic RT 3DDD method developed at the UI is feasible. The flow volume measurements correlated and agreed well with the flow volumes measured by PVC MRI and by LV volumetric measurement by MRI.
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Notes
Associated labs/groups:
Department of Pediatrics, The University of Iowa
Department of Radiology,
The University of Iowa
Text Reference
Honghai Zhang, Liping Bu, Alan Stolpen, Milan Sonka, Shuping Ge, "A Semi-Automatic Real-Time Three-Dimensional Digital Doppler Method for Measurement of Flow Volumes in Children:A Validation Using Cardiac Magnetic Resonant Imaging", Poster presented at American Heart Association, Scientific Session 2004.
BibTeX Reference
@article{Zhang_2004_AHA,
author = "Honghai Zhang, Liping Bu, Alan Stolpen, Milan Sonka, Shuping Ge",
title = "A Semi-Automatic Real-Time Three-Dimensional Digital Doppler Method for Measurement of Flow Volumes in Children:A Validation Using Cardiac Magnetic Resonant Imaging",
journal = "American Heart Association, Scientific Session",
year = "2004",
volume= "",
issue = "",
pages = ""
}